A female 62 years old, with late osteoarthritis of  left knee was performed a Total Knee Arthroplasty (TKA). Cemented femoral and tibial components; removal of  patellar osteophytes. Knee valgus 3⁰, sacrifice PCL (Posterior Cruciate Ligament). First 3-month  follow-up: no infection, no dislocation, range of motion: 0/0/90⁰, walk no pain, knee score: 90/100. 8-year follow-up : walk, slight run no pain; range of motion: 0/0/100⁰; knee score  evaluated  excellent: 95/100. The functional final outcome of this case is a superiority illustration   of Total Knee Arthroplasty for the osteoarthitis, especially in the late stage.

In quest of a stimulant to cope with rather challenging activities, some individuals take to the consumption of Cola nitida. The most active ingredient, caffeine, could be responsible for the physiological or clinical effects of Cola nitida in humans. Such a practice could culminate in the abuse of the said substance. Caffeine might alter hormonal profiles and thereby affect menstrual function, which might have a direct bearing on fertility. Amongst other factors, testosterone and progesterone are important to the chances of fertility in the humans. Besides, it has been well documented that the probability of pregnancy is reduced by 5% per unit of body mass index exceeding 29 kg/m² . From some published evidences of the high prevalence of infertility nowadays, the need for this study was thereby necessitated. Here we report the influence of Cola nitida on testosterone and progesterone concentrations in the normal weight humans under resting condition in Ambrose Alli University. Twenty (20) normal weight volunteers (10 males and 10 females) and non-habitual Cola nitida chewers, aged 18-28 years were used for the study. 0.5g/kg body weight of Cola nitida was administered to each subject to be chewed as a bolus. After ingestion, 50ml of water was given to each volunteer to flush the masticated Cola nitida down the gut. The subject was allowed to rest for 90 minutes. Blood sample was collected from the medial cubital vein using vacutainer syringe. The radio-immunoassay principle was used for the estimation of testosterone and progesterone levels. The results showed that Cola nitida consumption by the normal weight male and female subjects significantly (P<0.05) reduced serum level of progesterone in the females (from 16.47±039 ng/ml to 4.690±0.592 ng/ml) and serum testosterone level in the males (from 7.392±0.479 to 4.727±0.466 ng/ml). We show that Cola nitida, at the specific dosage, could reduce the chances of fertility in both the male and female normal weight subjects.

Background: The negative impact of medication overuse headache (MOH) on the quality of life (QoL) of the patient is undoubted.

Objective: The aim of this study was to identify clinical and headache related parameters that directly affect HRQoL of MOH patients.

Patients and Methods: 183 patients (111 men and 72 women) firstly diagnosed as having MOH and 81 healthy subjects (22 men and 59 women) in control group (CG) were enrloed in this study. The age of the study subjects range from 18 to 71 years. HRQoL was assessed using a Short Form - 36 questionnaire (SF-36), measuring its Physical Composite Score (PCS), Mental Composite Score (MCS) and Total score (TS).

Results: All HRQoL domeins (PCS, MCS, TS) were lower in MOH compared to the CG (p <0.001). In MOH, the depression itself is a risk factor for all aspects of HRQoL, for PCS (B = -0.70, 95% CI -1.32 - - 0.08, p = 0.027); for MCS (B = -0.71, 95% CI -1.14 - - 0.29, p = 0.001); for TS (B = -0.69, 95% CI -1.16 - - 0.22, p = 0.005)), with female gender being an associated risk factor only for PCS (B = -15.47, 95% CI -26.79 - - 4.14, p = 0.008). The results did not find a predictive role of anxiety, stress, and ruminative style of thinking for HRQoL in MOH patients (p>0.05).

Conclusions: Screening for depression among MOH patients and its treatment could be useful for improving their HRQoL

Study of paper is physiology use to analysis total  in LDH is an intracellular enzyme whose activity is associated with cellular metabolism, WBCs count in blood to patients which makes it a marker of cell proliferation and cell injury and study with molecular biology of marker parameters use drug the presence of survivin in neoplastic cells contributes to tumor development and its high transcription has been reported as a predictor of poor prognosis in several hematological malignancies. However, despite being frequently present in ALs, the impact of survivin transcription in this type of hematologic malignancy remains undefined. Some studies report that survivin predicts an unfavorable clinical outcome in ALs, while others do not. In the present study, despite the small number of patients evaluated, the transcription of survivin at diagnosis did not seem to be related to a worse response to treatment or a worse prognosis. This is because, of the six patients who expressed survivin, three are in complete remission and, of the three who died, two were already considered to have an unfavorable prognosis regardless of survivin transcription, one due to advanced age and the presence of leukocytosis in the liver. Leukometry at diagnosis was another prognostic factor evaluated in this study. Patients diagnosed with AL may have elevated, normal, or decreased WBC counts at the time of diagnosis and, in general, counts greater than 30,000 WBCs/mm3 are considered to have a poor prognosis.

The diagnosis of nanodiagnosis it is the use of nanodevices in an early detection at the cellular and molecular levels of diseases or their predestination. With In-vitro diagnostics, in order to evaluate the early existence of a disease, classify and quantify toxic molecules, tumeor cells or infectious diseases, nanotechnologies may improve the efficiency and sensitivity of diagnostic approaches by means of fluids such as saliva or tissue samples in which selective nanoscales perform multiple analyses on the subcellular scale. In the dental interest, the high mortality rate of oral squamous cell carcinoma is often attributed to difficulties in detecting the disease at an early treatable stage. In recent years, the ability of gold nanoparticles subjected to surface plasmon resonance capable of causing an optical contrast to discriminate between cancer and normal cells, and their conjugation with antibodies, has been explored, allowing the expression of relevant biomarkers to be traced for molecular imaging in the reflectance confocal microscope, demonstrating its potential for cancer detection in reflection based imaging systems on the basis of biomolecular changes.

Local anaesthesia: Local anaesthesia is one of the most common dental procedures. In recent years the development of bio-compatible microsphere and nanospheric drug regulated devices has turned them into ideal tools to use such anaesthetic substances to increase their protection, thereby reducing their physiologically harmful effects and reducing their effects by lacking vasoconstricting substances.