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Vol. 3 No. 2 (2023)

The Influence of Cola Nitida on Testosterone and Progesterone Concentrations in the Normal Weight Humans under Resting Condition in Ambrose Alli University

Clinical Medicine And Health Research Journal, Vol. 3 No. 2 (2023), 25 March 2023 , Page 329-335
https://doi.org/10.18535/cmhrj.v3i2.154

Abstract

In quest of a stimulant to cope with rather challenging activities, some individuals take to the consumption of Cola nitida. The most active ingredient, caffeine, could be responsible for the physiological or clinical effects of Cola nitida in humans. Such a practice could culminate in the abuse of the said substance. Caffeine might alter hormonal profiles and thereby affect menstrual function, which might have a direct bearing on fertility. Amongst other factors, testosterone and progesterone are important to the chances of fertility in the humans. Besides, it has been well documented that the probability of pregnancy is reduced by 5% per unit of body mass index exceeding 29 kg/m2 . From some published evidences of the high prevalence of infertility nowadays, the need for this study was thereby necessitated. Here we report the influence of Cola nitida on testosterone and progesterone concentrations in the normal weight humans under resting condition in Ambrose Alli University. Twenty (20) normal weight volunteers (10 males and 10 females) and non-habitual Cola nitida chewers, aged 18-28 years were used for the study. 0.5g/kg body weight of Cola nitida was administered to each subject to be chewed as a bolus. After ingestion, 50ml of water was given to each volunteer to flush the masticated Cola nitida down the gut. The subject was allowed to rest for 90 minutes. Blood sample was collected from the medial cubital vein using vacutainer syringe. The radio-immunoassay principle was used for the estimation of testosterone and progesterone levels. The results showed that Cola nitida consumption by the normal weight male and female subjects significantly (P<0.05) reduced serum level of progesterone in the females (from 16.47±039 ng/ml to 4.690±0.592 ng/ml) and serum testosterone level in the males (from 7.392±0.479 to 4.727±0.466 ng/ml). We show that Cola nitida, at the specific dosage, could reduce the chances of fertility in both the male and female normal weight subjects.

Keywords:
  • Cola nitida, fertility, testosterone, progesterone, radio-immunoassay.

How to Cite

ENS, I. ., O.E., E., O., O. ., E.E., E., HOT, B. ., A.A, T. ., & W.O, O. . (2023). The Influence of Cola Nitida on Testosterone and Progesterone Concentrations in the Normal Weight Humans under Resting Condition in Ambrose Alli University. Clinical Medicine And Health Research Journal, 3(2), 329–335. https://doi.org/10.18535/cmhrj.v3i2.154

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References

  • Alderette, E., Eskenazi, B. and Sholtz, R. (1995).Effect of cigarette smoking and coffee drinking on time to conception.Epidemiology6: 403-408
  • Armstrong, B.G, McDonald, A.D., and Sloan, M. Cigarette, alcohol and coffee consumption and spontaneous abortion.Am J Public Health, 82:85–87.
  • Benowitz, N. (1990). Clinical pharmacology of caffeine. Annual Review of Medicine, 41(1), 277–288.
  • Butt, W. R., & Blunt, S. M. (1988). The role of the laboratory in the investigation of infertility. Annals of Clinical Biochemistry, 25 ( Pt 6), 601–609.
  • Chavarro, J., Rich-Edwards, J., Rosner, B. and Willett, W. (2009) Caffeinated and alcoholic beverage intake in rela- tion to ovulatory disorder infertility. Epidemiology, 20(3), 374-381.
  • Chukwu L.O., Odiete W.O. and Briggs, L.S. (2006).Basal metabolic regulatory responses and rhythmic activity of mammalian heart to aqueous kolanut extracts. Afr. J. Biotech. 5: 484-486.
  • Chukwu L.U., Odiete W.O. and Briggs, L.S. (2006). Basal Metabolic Responses and Rhythmic Activity of Mammalian Hearts to Aqueous Kola nut extracts. African Journal of Biotechnology,5(5):484–486.
  • Cooper, Cyrus, and L. Joseph Melton III. "Epidemiology of osteoporosis." Trends in Endocrinology & Metabolism 3.6 (1992): 224-229.
  • Domingos, L. W. (1990). Role of substance P in the medial preoptic area in the regulation of gonadotropin and prolactin secretion in normal or orchidectomized rats. Neuroendocrinology, 51, 675–682.
  • Fenster, L., Quale, C., Waller, K., Windham, G.C., Elkin, E.P., Benowitz, N. and Swan, S.H. (1999).Caffeine con- sumption and menstrual function.American Journal of Epidemiology, 149(6), 550-557.
  • Ferin, M., Jewelewicz, R., & Warren, M. (1993). The menstrual cycle: physiology, reproductive disorders, and infertility. Oxford University Press.
  • Florack, E.I.M., Zielhuis, G.A., and Rolland, R. (1994).Cigarette smoking, alcohol consumption, and caffeine intake and fecundability.Prev Med23: 175-180
  • Gemmill, A. (2018). Perceived Subfecundity and Contraceptive Use Among Young Adult U.S. Women: Perceived subfecundity and contraceptive use. Perspectives on Sexual and Reproductive Health, 50(3), 119–127.
  • Gilbert, S. G., & Rice, D. C. (1991). Effects of chronic caffeine consumption in pregnant monkeys (Macaca fascicularis) on blood and urine clinical chemistry parameters. Fundamental and Applied Toxicology: Official Journal of the Society of Toxicology, 16(2), 299–308.
  • Gorelik, J., Harding, S. E., Shevchuk, A. I., Koralage, D., Lab, M., de Swiet, M., Korchev, Y., & Williamson, C. (2002). Taurocholate induces changes in rat cardiomyocyte contraction and calcium dynamics. Clinical Science (London, England: 1979), 103(2), 191–200.
  • Hackney, A. C. (1996). The male reproductive system and endurance exercise. Medicine and Science in Sports and Exercise, 28(2), 180–189.
  • Harlow, S.D. and Ephross, S.A. (1995). Epidemiology of menstruation and its relevance to women’s health.Epidemiol Rev,17: 265-286.
  • Igbinovia, F. O., Krupka, J., Hajek, P., Muller, Z., & Tlusty, J. (2020). Electricity storage in internet of renewable energy (IoRE) domain for sustainable smart cities. 2020 21st International Scientific Conference on Electric Power Engineering (EPE).
  • Igwe, J. C., & Onyegbado, C. C. (2007). A review of palm oil mill effluent (POME) water treatment. Global Journal of Environmental Research, 1(2), 54–62.
  • Infante-Rivard, C., Fernandez, A, Gauthier, R., David, M. and Rivard, G.E (1993). Fetal loss associated with caffeine intake before and during pregnancy. JAMA, 270:2940–2943.
  • Joesoef M, Beral V and Rolfs, R. (1990). Are caffeinated beverages risk factors for delayed conception.Lancet, 335: 136-137
  • Kitts, D. D. (1987). Studies on the estrogenic activity of a coffee extract. Journal of Toxicology and Environmental Health, 20(1–2), 37–49.
  • Meyer, J. W., Boli, J., Thomas, G. M., & Ramirez, F. O. (1997). World society and the nation‐state. American Journal of Sociology, 103(1), 144–181.
  • Miller, L. H., Good, M. F., & Milon, G. (1994). Malaria pathogenesis. Science (New York, N.Y.), 264(5167), 1878–1883.
  • Obika, L.F.O., Babatunde, E.O., Akoni, F.A., Adeeko, A.O., Nsaho, J., Reza, H. and Williams, S.A. (1996). Kola nut (kola nitida) enhances anti-diuretic activity in young dehydrated subjects. International Journal of Phytotherapy Research, 10: 563-568.
  • Ogutuga, D.B.A. (1975). Chemical composition and potential commercial uses of kolanuts, Cola nitida vent Cachott and EndlisherGh. J. Agri. Sci.8:121-125.
  • Olsen J. (1991). Cigarette smoking, tea and coffee drinking, and subfecundity. Am J Epidemiol,133: 734-739
  • Osim, E.E.and Udia, P.M. (1993). Effects of consuming a kolanut (Cola nitida) diet on mean arterial pressure in rats. International Journal Pharmacognosy,31:193– 197.
  • Parihar M. Obesity and infertility. Reviews in Gynecological Practice 2003; 3: 120-126.
  • Parkhurst, A.M., Korn, N., Thurston, R.J.(2000).The effects of methylxanthines on the mobility of stored turkey sperm.Poult Sci,79:1803–1809
  • Polan, M. L., DeCherney, A. H., Haseltine, F. P., Mezer, H. C., & Behrman, H. R. (1983). Adenosine amplifies follicle-stimulating hormone action in granulosa cells and luteinizing hormone action in luteal cells of rat and human ovaries. The Journal of Clinical Endocrinology and Metabolism, 56(2), 288–294.
  • Purgesleve, J.W. (1977). Tropical Crops Dicotiledons Longman’s London, 564-612.
  • Rall, T.W. (1990). Drugs used in the treatment of asthma.The methylxanthines, cromolyn sodium, and other agents. In: Goodman Gilman A, Rall TW, Nies AS, et al., eds. The pharmacological basis of therapeutics. Eighth ed. New York, NY: Pergamon press, 25.
  • Russel, T.A. (1955). The kola nut of Wet Africa World crops, 7: 221-225.
  • Schmiegelow, M. D., Andersson, C., Køber, L., Andersen, S. S., Olesen, J. B., Jensen, T. B., Azimi, A., Nielsen, M. B., Gislason, G., & Torp-Pedersen, C. (2014). Prepregnancy obesity and associations with stroke and myocardial infarction in women in the years after childbirth: a nationwide cohort study: A nationwide cohort study. Circulation, 129(3), 330–337.
  • Somorin, O. (1973). Spectrometry determination of caffeine in Nigerian kola nuts. Sci., 381: 911-913.
  • Stanton CK, Gray RH.(1995). Effects of caffeine consumption on delayed consumption. Am J Epidemiol, 142: 1322-1329
  • Tende, J.A., Ezekiel, I., Dare, S.S., Okpanachi, A.O., Kemuma, S.O. and Goji, A.D.(2011). Study of the effect of aqueous extract of kola nut (Cola nitida) on gastric acid secretion and ulcer in white wistar rats. Br J Pharmacol Toxicol, 2:132–134.
  • Togola, A., Austarheim, I., Diallo, A., Theisis, A. and Paulsen, B.S. (2008). Ethnopharmacological uses of Erythrina senegalensis, a comparison of three areas in Mali and link between traditional knowledge and modern biological science, Journal of Ethnobiology Ethnomedicine, 4: 6.
  • Umoren, E. B., Osim, E. E. and Udoh, P. B. (2009). The comparative effect of chronic consumption of kola nut (Cola nitida) and caffeine diets on locomotor behaviour and body weights in mice. Niger Journal of Physiological Science, 24(1):73-78.
  • Van Eijnatten, C. L. (1973). Kola: a review of the literature. Trop Abstr, 28(8).
  • Weathersbee, P.S. and Lodge, J.R. (1977). Caffeine: its direct and indirect influence on reproduction. J Reprod Med,19: 55-63
  • Willocks, J., & Neilson, J. P. (1991). Student notes. In Obstetrics and Gynaecology.
  • Wilson, S., MacRae, J. C., & Buttery, P. J. (1983). Glucose production and utilization in non-pregnant, pregnant and lactating ewes. The British Journal of Nutrition, 50(2), 303–316.
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