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Vol. 3 No. 4 (2023)

Study the Effects of the IL-1β -511 C>T Rs16944 SNP on the Incidence of Cardiomyopathy

Clinical Medicine And Health Research Journal, Vol. 3 No. 4 (2023), 1 July 2023 , Page 447-451
https://doi.org/10.18535/cmhrj.v3i4.195

Abstract

Background: The diseases that involve the myocardium directly and are not the result of hypertension, congenital, vascular, coronary, or pericardial abnormalities are called cardiomyopathy (CM). It is known that interleukin-1 (IL-1) family cytokines involve in inflammation and immune regulation and act as an important role in innate and adaptive immunity.


Aim: In this study, it was investigated the antioxidant capacity and their relation trace elements in cardiomyopathy CM patients and its correlation with IL-1β -511 C>T rs16944 SNP.


Methods: TAOC, and Cu-Zn SOD were determined by ELISA, and Cu and Zn were assessed by spectrophotometric method. IL-1β -511 C>T rs16944 SNP was assessed by PCR and DNA sequencing. 


Results: The results were conducted that no statistically significant difference in age between CM and CONT groups (P>0.05). The results showed that was a statistically significant decrease in TAOC and SOD levels in the CM group compared to the CONT group (P<0.001). There was a statistically significant decrease in Cu and Zn levels in the CM group compared to the CONT group (P<0.001). 


Conclusion: This study suggested that the essential role of antioxidant capacity and their trace elements affected by IL-1β -511 C>T rs16944 SNP as a risk factor for the incidence of CM in the Iraqi population.

How to Cite

Saeed Al-Mafragy, H. ., Hamzah, E. F. ., Neema AL-Mussawy, A. ., H. Kzar, H. ., & A. Al-Rubaie, Z. . (2023). Study the Effects of the IL-1β -511 C>T Rs16944 SNP on the Incidence of Cardiomyopathy . Clinical Medicine And Health Research Journal, 3(4), 447–451. https://doi.org/10.18535/cmhrj.v3i4.195

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