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Vol. 2 No. 5 (2022)

Evidence for Parainflammation According To Differential Leukocyte Ratios in a Cohort of Type 2 Diabetic Mellitus Patients

Clinical Medicine And Health Research Journal, Vol. 2 No. 5 (2022), 24 October 2022 , Page 240-244
https://doi.org/10.18535/cmhrj.v2i5.105

Abstract

Diabetes mellitus has over the years become a public health and a complex disease. It is characterized by chronic hyperglycemia. The present study was designed to determine the differential leukocyte ratios in type 2 diabetic patients compared to non-diabetic controls. A total of 240 subjects comprising 120 type 2 diabetic patients (60 males and 60 females) aged 20-25 years and 120 apparently healthy age and gender-matched controls were recruited for the study.  Blood samples (5.0ml) was collected from each subject for the analysis of the parameters using the Mindray 530 BC automated analyzer, Mindray, Japan.  The data was analyzed using T-test with level of significance set at p < 0.05.  The result revealed significant increase in the differential leukocyte ratios involving the Monocyte Lymphocyte Ratio (MLR) (0.38 + vs 0.15 +0.017) and the Neutrophil Lymphocyte Ratio (NLR) (3.15 + 3.57 vs 1.65 + 0.65) in the type 2 diabetic patients and the non-diabetic controls.  This finding demonstrates alterations in differential leukocyte ratios which supports occurrence of parainflammation in type 2 diabetic patients.

Keywords:
  • : type 2 diabetes, differential leukocyte ratios, parainflammation

How to Cite

Ogbonna Ogbuabor, A. ., Ogbuabor, M. C. ., & Chinwe Onyeka, I. . (2022). Evidence for Parainflammation According To Differential Leukocyte Ratios in a Cohort of Type 2 Diabetic Mellitus Patients. Clinical Medicine And Health Research Journal, 2(5), 240–244. https://doi.org/10.18535/cmhrj.v2i5.105

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